Ruta Navakauskiene Selected Research

Neoplasms (Cancer)

1/2019	Amyloid β oligomers inhibit growth of human cancer cells.
7/2015	Belinostat, a potent HDACi, exerts antileukaemic effect in human acute promyelocytic leukaemia cells via chromatin remodelling.
9/2014	Epigenetic and molecular mechanisms underlying the antileukemic activity of the histone deacetylase inhibitor belinostat in human acute promyelocytic leukemia cells.
12/2012	Histone deacetylase inhibitor BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.
12/2012	Antileukemic activity of combined epigenetic agents, DNMT inhibitors zebularine and RG108 with HDAC inhibitors, against promyelocytic leukemia HL-60 cells.
11/2012	DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodelling.
1/2012	Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells.
12/2006	Retinoic acid and histone deacetylase inhibitor BML-210 inhibit proliferation of human cervical cancer HeLa cells.

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Ruta Navakauskiene Research Topics

Disease

13	Leukemia 11/2018 - 12/2002
8	Neoplasms (Cancer) 01/2019 - 12/2006
5	Acute Promyelocytic Leukemia 01/2019 - 12/2004
2	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/2014 - 01/2012
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/2012 - 12/2006
1	Fibrosis (Cirrhosis) 01/2023
1	Infertility (Sterility) 01/2023
1	Mental Disorders (Mental Disorder) 01/2021
1	Schizophrenia (Dementia Praecox) 01/2021
1	Breast Neoplasms (Breast Cancer) 01/2019
1	Lung Neoplasms (Lung Cancer) 01/2019
1	Breast Ductal Carcinoma 01/2019
1	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2018
1	Myeloid Leukemia (Leukemia, Myelocytic) 11/2018
1	Carcinogenesis 07/2014
1	Muscular Dystrophies (Muscular Dystrophy) 12/2012
1	Carcinoma (Carcinomatosis) 12/2006
1	Lymphoma (Lymphomas) 12/2006

Drug/Important Bio-Agent (IBA)

9	Histone Deacetylase InhibitorsIBA 09/2014 - 11/2006
6	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2014 - 12/2002
4	N1- (2- aminophenyl)- N8- phenyloctanediamideIBA 12/2012 - 11/2006
3	Histones (Histone)IBA 07/2014 - 12/2006
3	Proteins (Proteins, Gene)FDA Link 12/2012 - 12/2002
3	Butyrates (Butyrate)IBA 01/2012 - 12/2006
3	Transcription Factors (Transcription Factor)IBA 01/2011 - 12/2004
2	BIX 01294IBA 11/2018 - 07/2014
2	belinostatIBA 07/2015 - 09/2014
2	Histone Deacetylases (Histone Deacetylase)IBA 09/2014 - 08/2009
2	pyrimidin-2-one beta-ribofuranosideIBA 12/2012 - 01/2012
2	romidepsin (FK228)FDA Link 01/2011 - 12/2006
2	Niacinamide (Nicotinamide)FDA LinkGeneric 01/2011 - 12/2006
2	SodiumIBA 01/2011 - 12/2006
2	NF-kappa B (NF-kB)IBA 12/2006 - 12/2004
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 01/2019
1	Amyloid beta-PeptidesIBA 01/2019
1	Amyloid (Amyloid Fibrils)IBA 01/2019
1	epigallocatechin gallate (epigallocatechin-3-gallate)IBA 11/2018
1	Lysine (L-Lysine)FDA Link 07/2014
1	MethyltransferasesIBA 07/2014
1	Histone MethyltransferasesIBA 07/2014
1	NucleosidesIBA 12/2012
1	1,2- diarachidonoyl- glycero- 3- phosphocholineIBA 12/2012
1	RG108IBA 12/2012
1	CytidineIBA 01/2012
1	Cadherins (E-Cadherin)IBA 01/2012
1	ChromatinIBA 01/2011
1	Growth InhibitorsIBA 12/2006
1	DepsipeptidesIBA 12/2006
1	Histone Deacetylase 1IBA 12/2006
1	Etoposide (VP 16)FDA LinkGeneric 12/2004
1	phorbolIBA 12/2004
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 12/2004
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 12/2004
1	CaspasesIBA 12/2004
1	Tyrosine (L-Tyrosine)FDA Link 04/2004
1	Protein Isoforms (Isoforms)IBA 12/2002
1	dystrobrevinIBA 12/2002

Therapy/Procedure

7	Therapeutics 01/2023 - 01/2012
1	Drug Therapy (Chemotherapy) 01/2023